Tacrolimus Dose Adjustment Calculator
This tool provides an estimated tacrolimus dose adjustment based on current and target trough levels. It is intended for informational purposes by healthcare professionals and patients under medical supervision.
This calculator is for informational and educational purposes only. It is NOT a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication adjustment.
Never disregard professional medical advice or delay in seeking it because of something you have read or calculated here. Dose adjustments should ONLY be made by a qualified healthcare professional familiar with the patient’s specific clinical situation.
Understanding Tacrolimus Dosing
Tacrolimus is an immunosuppressant medication, primarily used after organ transplantation to prevent rejection. It has a narrow therapeutic index, meaning the range between effective doses and toxic doses is small. Therefore, blood levels are regularly monitored.
Trough Levels: The “trough level” is the concentration of the drug in the blood just before the next dose is due. This is usually the lowest concentration and is used to guide dosing adjustments.
Target Ranges: Target trough levels vary depending on the type of transplant, time since transplant, individual patient factors, and institutional protocols. For example:
- Kidney Transplant (maintenance): Typically 5-10 ng/mL
- Liver Transplant (maintenance): Typically 5-10 ng/mL
- Heart Transplant (maintenance): Typically 5-15 ng/mL (can be higher initially)
These are general examples; always refer to specific guidelines and individual patient needs.
Calculation Method: This calculator uses a simple proportional adjustment:
New Dose = Current Dose × (Target Level / Current Level)
The calculated dose is an estimate. Actual dose adjustments should consider clinical context, available dosage strengths (e.g., 0.5mg, 1mg, 5mg capsules), and potential for rounding. Significant changes should be made cautiously.